Publications & Projects
Selected Publications
Chen GM, Chen C, Grupp SA, Barrett DM, Tan K. Characterization of leukemic resistance to CD19 targeted CAR T-cell therapy through deep genomic sequencing.
Cancer Immunology Research (2022).
Chen GM#, Melenhorst JJ, Tan K#. B-cell targeting in CAR T cell therapy: side effect or biological driver of CAR T-cell function?
Science Translational Medicine (2022).
Melenhorst JJ*#, Chen GM*, Wang M*, Porter DL*, Chen C, Collins MA, Gao P, Bandyopadhyay S, Sun H, Zhao Z, Lundh S, Pruteanu-Malinici I, Nobles CL, Maji S, Frey NV, Gill SI, Tian L, Kulikovskaya I, Gupta M, Ambrose DE, Davis MM, Fraietta JA, Brogdon JL, Young RM, Chew A, Levine BL, Siegel DL, Alanio C, Wherry EJ, Bushman FD, Lacey SF, Tan K#, June CH#. Decade-long leukemia remissions with persistence of CD4+ CAR T cells.
Nature (2022).
Chen GM*, Chen C*, Das RK*, Gao P, Chen C, Bandyopadhyay S, Ding YY, Uzun Y, Yu W, Zhu Q, Myers RM, Grupp SA, Barrett DM#, Tan K#. Integrative bulk and single-cell profiling of pre-manufacture T-cell populations reveals factors mediating long-term persistence of CAR T-cell therapy.
Cancer Discovery (2021).
Chen GM, Azzam A, Ding YY, Barrett DM, Grupp SA, Tan K. Dissecting the tumor-immune landscape in chimeric antigen receptor T-cell therapy: key challenges and opportunities for a systems immunology approach.
Clinical Cancer Research (2020).
Chen GM, Pather SR, DeLisser HM. Trends in the Use of Common Words and Patient-Centric Language in the Titles of Medical Journals, 1976-2015.
JAMA Network Open (2019).
Chen GM*, Kannan L*, Geistlinger L, Kofia V, Safikhani Z, Gendoo DM, Parmigiani G, Birrer M, Haibe-Kains B#, Waldron L#. Consensus on Molecular Subtypes of High-Grade Serous Ovarian Carcinoma.
Clinical Cancer Research (2018).
Dejong CA*, Chen GM*, Li H*, Johnston CW, Edwards MR, Rees PN, Skinnider MA, Webster ALH, Magarvey NA. Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching.
Nature Chemical Biology (2016).
* = Co-first authors
# = Joint corresponding authors
Contributing Author Publications
Ding YY, Kim H, Madden K, Loftus JP, Chen GM, Allen DH, Zhang R, Xu J, Hu Y, Tasian SK, Tan K. Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia.
Clinical Cancer Research (2021).
He B, Gao P, Ding Y, Chen C, Chen GM, Chen C, Kim H, Tasian SK, Hunger SP, Tan K. Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers.
Science Advances (2020).
Gendoo DMA, Zon M, Sandhu V, Manem VSK, Ratanasirigulchai N, Chen GM, Waldron L, Haibe-Kains B. MetaGxData: Clinically Annotated Breast, Ovarian and Pancreatic Cancer Datasets and their Use in Generating a Multi-Cancer Gene Signature.
Scientific Reports (2019).
P’ng C, Green J, Chong LC, Waggott D, Prokopec SD, Shamsi M, Nguyen F, Mak DYF, Lam F, Albuquerque MA, Wu Y, Jung EH, Starmans MHW, Chan-Seng-Yue MA, Yao CQ, Liang B, Lalonde E, Haider S, Simone NA, Sendorek D, Chu KC, Moon NC, Fox NS, Grzadkowski MR, Harding NJ, Fung C, Murdoch AR, Houlahan KE, Wang J, Garcia DR, Borja RD, Sun RX, Lin X, Chen GM, Lu A, Shiah Y, Zia A, Kearns R, Boutros PC. BPG: seamless, automated and interactive visualization of scientific data.
BMC Bioinformatics (2019).
Heng YJ, Lester SC, Tse GMK, Factor RE, Allison KH, Collins LC, Chen Y, Jensen KC, Johnson NB, Jeong JC, Punjabi R, Shin SJ, Singh K, Krings G, Eberhard DA, Tan PH, Korski K, Waldman FM, Gutman DA, Sanders M, Reis-Filho JS, Flanagan SR, Gendoo DMA, Chen GM, Haibe-Kains B, Ciriello G, Hoadley KA, Perou CM, Beck AH. The molecular basis of breast cancer pathological phenotypes.
The Journal of Pathology (2017).
Noren DP, Long B, Norel R, Rrhissorrakrai K, Hess K, Hu W, Bisberg A, Schultz A, Engquist E, Liu L, Lin X, Chen GM, Xie H, Hunter GAM, Boutros PC, Stepanov O, DREAM 9 AML OPC Consortium, Norman T, Friend SH, Stolovitzky G, Kornblau S, Qutub AA. A Crowd Sourcing Approach to Developing and Assessing Prediction Algorithms for AML Prognosis.
PLoS Computational Biology (2016).
Johnston CW, Skinnider MA, Dejong C, Rees P, Chen GM, Walker C, French S, Brown ED, Berdy J, Liu D, Magarvey NA. Collecting and clustering natural antibiotics guides identification of evolved targets.
Nature Chemical Biology (2016).
Turcotte M, Spring K, Pommey S, Chouinard G, Cousineau I, Gorges J, Chen GM, Gendoo DM, Haibe-Kains B, Karn T, Rahimi K, Le Page C, Provencher DM, Mes-Masson AM, Stagg J. CD73 is associated with poor prognosis in high-grade serous ovarian cancer.
Cancer Research (2015).
Boutros PC, Fraser M, Harding NJ, de Borja R, Trudel D, Lalonde E, Meng A, Hennings-Yeomans PH, McPherson A, Sabelnykova VY, Zia A, Fox NS, Livingstone J, Shiah Y, Wang J, Beck TA, Have CL, Chong T, Sam M, Johns J, Timms L, Buchner N, Wong A, Watson JD, Simmons TT, P’ng C, Zafarana G, Nguyen F, Luo X, Chu KC, Prokopec SD, Sykes J, Dal Pra A, Berlin A, Brown A, Chan-Seng-Yue MA, Yousif F, Denroche RE, Chong LC, Chen GM, Jung E, Fung C, Starmans MHW, Chen H, Govind SK, Hawley J, D’Costa A, Pintilie M, Waggott D, Hach F, Lambin P, Muthuswamy LB, Cooper C, Eeles R, Neal D, Tetu B, Sahinalp C, Stein LD, Fleshner N, Shah SP, Collins CC, Hudson TJ, McPherson JD, van der Kwast T, Bristow RG. Spatial genomic heterogeneity within localized, multifocal prostate cancer.
Nature Genetics (2015).
Projects
A summary of some academic and personal projects that I have worked on
